Dear prof. Benso,
It is a pleasure to accept your manuscript entitled “One DB to rule them all” – The RING: a Regulatory INteraction Graph combining TFs, genes/proteins, SNPs, diseases, and drugs.” in its current form for publication in DATABASE.
Politano, G., Di Carlo, S. and Benso, A. ‘One DB to rule them all’ — the RING: a Regulatory INteraction Graph combining TFs, genes/proteins, SNPs, diseases and drugs. Database (2018) Vol. 2019: article ID baz108; doi: 10.1093/database/baz108
Abstract
In the last decade, genomics data have been largely adopted to sketch, study and better understand the complex mechanisms that underlie biological processes. The amount of publicly available data sources has grown accordingly, and several types of regulatory interactions have been collected and documented in literature. Unfortunately, often these efforts do not follow any data naming/interoperability/formatting standards, resulting in high-quality but often uninteroperable heterogeneous data repositories. To efficiently take advantage of the large amount of available data and integrate these heterogeneous sources of information, we built the RING (Regulatory Interaction Graph), an integrative standardized multilevel database of biological interactions able to provide a comprehensive and unmatched high-level perspective on several phenomena that take place in the regulatory cascade and that researchers can use to easily build regulatory networks around entities of interest.
BibTEX
@Article{Politano2019,
author="Politano, Gianfranco
and Di Carlo, Stefano",
title="One DB to rule them all’ — the RING: a Regulatory INteraction Graph combining TFs, genes/proteins, SNPs, diseases and drugs",
year="2019",
volume="2019",
number="Article ID baz108",
pages="1--14",
issn="1758-0463",
doi="10.1093/database/baz108",
url="http://dx.doi.org/10.1093/database/baz108"
}
Access
the RING Database is freely accessible through our servers at https://precious.polito.it/theringdb/home